These Are the Binds that Tie

Authorship and industry financial relationships: the tie that binds.

Another Tie that Binds the MTA Family to Breast Cancer

In this issue of Cell, demonstrate that MTA3 is an estrogen-dependent component of the NuRD complex and identify the Snail gene as its direct target. ER signaling upregulates MTA3 levels to negatively modulate Snail-mediated repression of E-cadherin. These findings may explain how ER status controls epithelial-to-mesenchymal transition in human breast tumors.

Activation of matrix metalloproteinases in the failing human heart: breaking the tie that binds.

The process of left ventricular (LV) remodeling has been shown to be an important predictor of morbidity and mortality in patients with heart failure. Therefore, identifying the cascade of molecular and cellular events that contribute to LV remodeling is likely to provide new and novel targets for preventing disease progression in heart failure. In this issue of Circulation, Li and colleagues r...

The tie that binds? Coherence among emotion experience, behavior, and physiology.

Emotion theories commonly postulate that emotions impose coherence across multiple response systems. However, empirical support for this coherence postulate is surprisingly limited. In the present study, the authors (a) examined the within-individual associations among experiential, facial behavioral, and peripheral physiological responses during emotional responding and (b) assessed whether em...

Freedom And The Tie That Binds: Marriage As An Ethical Institution

The issue of the breakdown of the marriage bond in Western societies has become a routine object of social and moral concern, political and public debate. This is striking, given that in most non-western cultures still and in every society heretofore, marriage has been insisted upon as the required precondition for the mating of men and women as the act that initiates and sustains the family or...